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KMID : 0357919680020010001
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Korean Journal of Pathology
1968 Volume.2 No. 1 p.1 ~ p.13
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Experimental Studios on the Influence of Cortisone and ACTH upon Antibody Formation in the Rabbit
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박숙현(朴淑鉉)/Sook Hyun Park
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Abstract
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An experimental study on the influence of cortisone and ACTH upon the antibody
formation in rabbit was performed counting the pyroninophilic cells in the spleen,
lymphnode and thymus.
The following results and conclusion were obtained.
1. Administration of cortisone and ACTH with immunization produced a decreased
number of pyroninophilic cells in the spleen and lymphnodes comparing that of the
controls.
2. This suppressive effects of cortisone and ACTH on the pyroninophilic cells were
prominent in the rabbits that has been treated with cortisone and ACTH prior to
immunization, simulataneous treatment and post-immunization treatment in decreasing
order of elects.
3. Cortisone seems to have stronger effects on the pyroninophilic cells in rabbits
comparing that of ACTH though it is influenced by the time of immunization.
4. Cortisone and ACTH administration without antigenic stimulation also produced a
slighthy increased pyroninophilic cells in the lymphoid tissues.
5. Pyroninophilic cells in the thymus of the mature rabbits are negligible in number
and seems not influenced by the treatment of cortisone and ACTH with or without
immunization.
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